Current Research Projects
Dietary Micronutrients in gut-host interaction.
Funded by NSERC.
Vitamin B6 and pathophysiology of non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) is a complex disorder with multiple contributing factors that affects a significant portion of the global population. A growing body of evidence suggests a link between dietary micronutrients and NAFLD, specifically impairments in one-carbon (1C) metabolism. Furthermore, vitamin deficiencies, including vitamin B6, have been associated with an increased risk of NAFLD and heightened susceptibility to severe liver damage. This correlation is attributed to increased oxidative stress, inflammation, hepatic lipotoxicity, altered immune function, and gut dysbiosis. Consistent with prior reports, lower levels of vitamin B6 have been observed in individuals with chronic liver diseases, including alcoholic and non-alcoholic fatty liver disease. These findings underscore the critical role of specific vitamins in preventing the onset of metabolic diseases. Therefore, we aim to investigate the effects of deficiencies in B6 on the development and progression of NAFLD.
Funded by Memorial University
Remodeling kynurenine metabolism in pediatric non-alcoholic fatty liver disease
Funded by Janeway Research Foundation